Finding Dory had opened biggest domestic opening of all time for an animated film with $136.2 million, beating out the previous record holder, Shrek the Third. In a distant second place was the Dwayne Johnson/Kevin Hart action comedy Central Intelligence, which made more than $100 million less than Dory. Blockbuster genre films like Warcraft, Teenage Mutant Ninja Turtles: Out of the Shadows, X-Men: Apocalypse, and Captain America: Civil War are dominating the box office, as is typical for this time of the year.
| TW | LW | Title (click to view) | Studio | Weekend Gross | % Change | Theater Count / Change | Average | Total Gross | Budget* | Week # | |
| 1 | N | Finding Dory | BV | $136,183,170 | – | 4,305 | – | $31,634 | $136,183,170 | – | 1 |
| 2 | N | Central Intelligence | WB | $34,500,000 | – | 3,508 | – | $9,835 | $34,500,000 | $50 | 1 |
| 3 | 1 | The Conjuring 2 | WB | $15,555,000 | -61.5% | 3,356 | +13 | $4,635 | $71,730,086 | $40 | 2 |
| 4 | 3 | Now You See Me 2 | LG/S | $9,650,000 | -56.9% | 3,232 | – | $2,986 | $41,362,529 | – | 2 |
| 5 | 2 | Warcraft | Uni. | $6,520,000 | -73.0% | 3,406 | +6 | $1,914 | $37,711,525 | $160 | 2 |
| 6 | 5 | X-Men: Apocalypse | Fox | $5,210,000 | -47.5% | 2,632 | -953 | $1,979 | $146,057,836 | $178 | 4 |
| 7 | 4 | Teenage Mutant Ninja Turtles: Out of the Shadows | Par. | $5,200,000 | -63.9% | 3,086 | -985 | $1,685 | $71,929,574 | $135 | 3 |
| 8 | 6 | Me Before You | WB | $4,155,000 | -54.0% | 2,645 | -117 | $1,571 | $46,355,854 | $20 | 3 |
| 9 | 8 | Alice Through the Looking Glass | BV | $3,615,385 | -36.0% | 1,880 | -1,018 | $1,923 | $69,318,309 | $170 | 4 |
| 10 | 9 | Captain America: Civil War | BV | $2,296,207 | -46.8% | 1,434 | -667 | $1,601 | $401,277,176 | $250 | 7 |